SA researchers HIV cure shows promising results, cure could soon be found

By Hans Ngala (with details from UKZN)

The University of KwaZulu-Natal (UKZN) in South Africa has conducted an HIV cure trial in the South African city of Durban which “has demonstrated promising results in achieving antiretroviral therapy (ART)-free virus control” the university reported. The University said this would be “A first for Africa, the HIV cure trial shows that 20% of trial participants remain off ART and are virally suppressed after one-and-a-half years”.

The results of the study were presented at the 2025 Conference on Retroviruses and Opportunistic Infections (CROI) which took place from 9 – 12 March 2025 in San Francisco, USA.

The study tested a promising HIV treatment approach called combination immunotherapy. The goal was to either eliminate or reduce hidden traces of HIV in the body so the immune system could keep the virus in check without the need for lifelong medication.

In the study, the first HIV cure clinical trial in Africa, the researchers treated participants with antiretrovirals very soon after they acquired HIV. Once the virus was controlled by ART, they administered powerful immune-boosters – which helps the immune system fight the virus more effectively. Under close medical supervision, participants then stopped ART to see if their bodies could control the virus on their own.

Twenty women were enrolled in the trial – a significant milestone because women are a group disproportionately affected by HIV yet are often underrepresented in cure-related research. The trial results show that 30% of participants (six out of 20) were able to stay off HIV treatment for nearly a year, and 20% (four participants) remained off treatment until the trial ended at 55 weeks. Even after the trial, these four individuals, who are still being closely monitored, have continued without medication for an average of 1.5 years.

UKZN’s Professor Thumbi Ndung’u who led the trial study said “While this treatment approach didn’t work for most participants, it is still a significant development in HIV cure research. Studying how the 20% managed to control the virus on their own will help scientists develop better HIV cure strategies, as well as work out ways to improve future treatments.”

“This trial is also significant because it proves that complex HIV cure research can be successfully conducted in resource-limited settings where the need is greatest, and highlights the importance of including African populations in global scientific advancements.”

Professor Busisiwe Ncama, Deputy vice-chancellor and Head: College of Health Sciences said, “Heartfelt congratulations to Professor Thumbi Ndung’u and his team on their groundbreaking achievement in HIV cure research—the first of its kind in Africa. Your pioneering study, which has shown that 20% of trial participants remain off ART and virally suppressed after one-and-a-half years, marks a significant milestone in the global fight against HIV. This extraordinary breakthrough not only brings hope to millions but also paves the way for future HIV cure strategies. Your dedication, innovation and unwavering commitment to scientific excellence continues to inspire us all. We are immensely proud of your leadership and the impact of your work on healthcare both in South Africa and globally. On behalf of the UKZN community, I salute you for this remarkable success and look forward to seeing your research transform lives in the years to come.”